Treatment Resistant Depression (TRD), Bipolar and Postpartum Depression (PPD)

Thrive IV offers physician-administered ketamine infusion therapy for treatment-resistant depression, bipolar depression, and postpartum depression at our Dartmouth, Massachusetts clinic. When at least one adequate antidepressant trial hasn’t worked — which happens for a large share of patients — ketamine offers a different mechanism, acting on NMDA receptors and promoting neuroplasticity. Published studies report meaningful responses in roughly 70–80% of patients, and many begin to feel better within hours to days. A typical starting course is six infusions over three weeks, each given and monitored by Dr. Michael Pellegrino, DO, and coordinated with your existing psychiatrist or therapist.

In addition to IV infusions, Thrive IV offers compounded nasal ketamine therapy for patients with treatment-resistant depression. Nasal ketamine uses the same racemic ketamine as our infusions in a spray form and is administered in our office under physician supervision. Dr. Pellegrino will review your history and discuss whether IV or nasal delivery is the better fit for you.

Depression symptoms can vary from mild to severe and can include:

• Feeling sad or having a depressed mood
• Loss of interest or pleasure in activities once enjoyed
• Changes in appetite — weight loss or gain unrelated to dieting
• Trouble sleeping or sleeping too much
• Loss of energy or increased fatigue
• Increase in purposeless physical activity (e.g., inability to sit still, pacing, handwringing) or slowed movements or speech (these actions must be severe enough to be observable by others)
• Feeling worthless or guilty
• Difficulty thinking, concentrating or making decisions
• Thoughts of death or suicide

Symptoms must last at least two weeks and must represent a change in your previous level of functioning for a diagnosis of depression.

Treatment-resistant depression (TRD), Bipolar and PPD typically refers to inadequate response to at least one antidepressant trial of adequate doses and duration. TRD is a relatively common occurrence in clinical practice, with up to 60% of the patients not achieving adequate response following antidepressant treatment.

Ketamine therapy has been shown to help as many as 70-80% or more in some studies. We specialize in adding Ketamine infusions to help increase your feeling of well being and reduce the terrible pain, depression or anxiety you've been experiencing. Giving you hope to live a happier and more productive, fulfilled life.